The essential oil from Kelussia odoratissimaMozaff. fruits exerting potent analgesic and anti-inflammatory effects

Kelussia odoratissimafruits are utilized in Persian traditional medicine as a painkiller and to prevent inflammation-based disorders. Considering the higher content of essential oil fruits, oil’s anti-inflammatory analgesic activities were investigated via paw edema triggered mice writhing test hot plate technique, respectively. It was observed that 100, 200 mg/Kg doses revealed an impact (p<0.001) considering increment reaction time needed for approach. Furthermore, 100 caused reduction frequency writhes (p<0.01 p<0.001, respectively). Using all examined theoil (25, 50, mg/Kg) inflammatory (p<0.001). The findings indicated possess significant against acute inflammation. had both peripheral central pain-killing impacts. main components 3-n-butylphthalide (28.3%) germacrene D (17.3%) can be considered responsible compounds manage inflammation pain.